CHIRON efficiency tests

CHIRON efficiency

Automated minimization of steric clashes in protein structures.

Molecular modeling of proteins including homology modeling, structure determination, and knowledge-based protein design requires tools to evaluate and refine three-dimensional protein structures. Steric clash is one of the artifacts prevalent in low-resolution structures and homology models. Steric clashes arise due to the unnatural overlap of any two nonbonding atoms in a protein structure. Us...

Light fermion masses and chiral freedom

Within the scenario of chiral freedom we compute the quark and lepton masses of the first two generations in terms of their chiral couplings. This allows us to make a rough estimate of the size of the chiral couplings, narrowing down the uncertainty in the chiron contribution to low energy observables, like the anomalous magnetic moment of the muon. We also extract information about the chiron ...

Analysis of hepatitis C virus isolates using molecular and serological typing methods.

This study comprised 100 persons with antibodies to hepatitis C virus (HCV), including 77 intravenous drug users (IVDUs). They were tested with serological HCV typing assays (Murex HCV serotyping 1-6 assay; Chiron RIBA HCV Serotyping SIA). Patients with a positive polymerase chain reaction (PCR) for HCV (n = 66) were tested with genotyping molecular assays (Inno-Lipa HCV II test; Sorin GEN-ETI-...

Role of signal-to-cutoff ratios in hepatitis C virus antibody detection.

We reviewed results from 12,800 samples tested for hepatitis C virus (HCV) antibody detection in our laboratory by screening (Ortho chemiluminescence immunoassay [CIA]) and supplemental tests (Chiron recombinant immunoblot assay [RIBA]). We found that a signal-to-cutoff (S/Co) ratio of 10.3 was, in our setting, the most efficient cutoff point to improve the diagnostic algorithm of HCV infection.